Nonfermentative gram-negative bacilli in cancer patients: increasing frequency of infection and antimicrobial susceptibility of clinical isolates to fluoroquinolones.

Abstract

Despite a decline in the frequency of gram-negative infections in cancer patients, there has been an increase in the proportion of such infections caused by nonfermentative gram-negative bacilli (NFGNB). We tested the in vitro activity of several quinolones against NFGNB isolated from cancer patients between February 2000 and February 2003, using a broth microdilution method. Ciprofloxacin was the most potent agent tested against Pseudomonas aeruginosa, although only 80% of isolates were susceptible to it. The newer quinolones (gatifloxacin, moxifloxacin, and garenoxacin) had better activity than ofloxacin, levofloxacin, and ciprofloxacin, against many other nonfermenters (Stenotrophomonas maltophilia, P. fluorescens, and P. putida).

05001000'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

1,478 Citations

Semantic Scholar estimates that this publication has 1,478 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Rolston2005NonfermentativeGB, title={Nonfermentative gram-negative bacilli in cancer patients: increasing frequency of infection and antimicrobial susceptibility of clinical isolates to fluoroquinolones.}, author={Kenneth V I Rolston and Dimitrios P Kontoyiannis and Davood Yadegarynia and Issam I Raad}, journal={Diagnostic microbiology and infectious disease}, year={2005}, volume={51 3}, pages={215-8} }