Nonequivalent requirements for PS1 and PS2 integrin at cell attachments in Drosophila: genetic analysis of the alpha PS1 integrin subunit.

@article{Brower1995NonequivalentRF,
  title={Nonequivalent requirements for PS1 and PS2 integrin at cell attachments in Drosophila: genetic analysis of the alpha PS1 integrin subunit.},
  author={Danny L. Brower and Thomas A. Bunch and Leona Mukai and Todd E. Adamson and Marcel Wehrli and S Lam and Eric Friedlander and Carol E. Roote and Susan B Zusman},
  journal={Development},
  year={1995},
  volume={121 5},
  pages={1311-20}
}
We report on the generation and phenotype of mutant alleles of multiple edematous wings (mew), the gene encoding the alpha PS1 subunit of the PS1 integrin of Drosophila. None of the six alleles examined makes detectable protein, and one allele results from a chromosome break near the middle of the translated sequence, so we are confident that we have described the null phenotype. In contrast to if (alpha PS2) and mys (beta PS) mutants, most mutant mew embryos hatch, to die as larvae. Mutant mew… CONTINUE READING
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