Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell-surface expression.

  title={Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell-surface expression.},
  author={E Kaldjian and Susan A. McCarthy and Susan O. Sharrow and Dan R. Littman and Richard D. Klausner and Alfred Singer},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={2 12},
The membrane glycoproteins CD4 (L3T4) and CD8 (Lyt2) are expressed on distinct populations of mature murine T lymphocytes, and are thought to be receptors for monomorphic determinants expressed on MHC class II and class I molecules, respectively. Although they differ in their ligand specificity, it has been presumed that CD4 and CD8 perform equivalent functions in the T cells that bear them. Since activation of protein kinase C (PKC) is known to cause rapid down-regulation of various receptors… CONTINUE READING

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