Nonequilibrium phase transition in a mesoscoipic biochemical system : From stochastic to nonlinear dynamics and beyond

@inproceedings{Ge2009NonequilibriumPT,
  title={Nonequilibrium phase transition in a mesoscoipic biochemical system : From stochastic to nonlinear dynamics and beyond},
  author={Hao Ge and H. P. Qian},
  year={2009}
}
A rigorous mathematical framework for analyzing the chemical master equation (CME) with bistability, based on the theory of large deviation, is proposed. Using a simple phosphorylation-dephosphorylation cycle with feedback as an example, we show that a nonequilibrium steady-state (NESS) phase transition occurs in the system which has all the characteristics… CONTINUE READING