Nonenzymatic polyubiquitination of expressed proteins.

  title={Nonenzymatic polyubiquitination of expressed proteins.},
  author={Hosahalli P Hemantha and Sudhir N Bavikar and Yifat Herman-Bachinsky and Najat Haj-Yahya and Somasekhar Bondalapati and Aaron Ciechanover and Ashraf Brik},
  journal={Journal of the American Chemical Society},
  volume={136 6},
Ubiquitination is one of the most ubiquitous posttranslational modifications in eukaryotes and is involved in various cellular events such as proteasomal degradation and DNA repair. The overwhelming majority of studies aiming to understand ubiquitination and deubiquitination have employed unanchored ubiquitin chains and mono-ubiquitinated proteins. To shed light on these processes at the molecular level, it is crucial to have facile access to ubiquitin chains linked to protein substrates. Such… CONTINUE READING
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