Nonenzymatic nitric oxide production in humans.

  title={Nonenzymatic nitric oxide production in humans.},
  author={Eddie Weitzberg and Jon O N Lundberg},
  journal={Nitric oxide : biology and chemistry},
  volume={2 1},
The tiny diatomic gas nitric oxide is synthezised in biological systems by complex enzymes known as nitric oxide synthases. Recently, a novel pathway for NO production in humans was discovered that involves chemical reduction of inorganic nitrite, a reaction that takes place predominantly during acidic and reducing conditions. Nonenzymatic NO production has been demonstrated, e.g., in the stomach, on the surface of the skin, in the ischemic heart, and in infected nitrite-containing urine. NO… CONTINUE READING

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