Nondestructive evaluation of progressive neuronal changes in organotypic rat hippocampal slice cultures using ultrahigh-resolution optical coherence microscopy.

@article{Li2014NondestructiveEO,
  title={Nondestructive evaluation of progressive neuronal changes in organotypic rat hippocampal slice cultures using ultrahigh-resolution optical coherence microscopy.},
  author={Fengqiang Li and Yu Song and Alexandra M Dryer and William Cogguillo and Yevgeny Berdichevsky and Chao Zhou},
  journal={Neurophotonics},
  year={2014},
  volume={1 2},
  pages={
          025002
        }
}
Three-dimensional tissue cultures have been used as effective models for studying different diseases, including epilepsy. High-throughput, nondestructive techniques are essential for rapid assessment of disease-related processes, such as progressive cell death. An ultrahigh-resolution optical coherence microscopy (UHR-OCM) system with [Formula: see text] axial resolution and [Formula: see text] transverse resolution was developed to evaluate seizure-induced neuronal injury in organotypic rat… CONTINUE READING
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