Noncore residues influence the kinetics of functional TTR(105-115)-based amyloid fibril assembly.

@article{Bongiovanni2012NoncoreRI,
  title={Noncore residues influence the kinetics of functional TTR(105-115)-based amyloid fibril assembly.},
  author={Marie Nicole Bongiovanni and Dhivya J Puri and Kenneth N. Goldie and Sally L Gras},
  journal={Journal of molecular biology},
  year={2012},
  volume={421 2-3},
  pages={256-69}
}
Mutations in the polypeptide sequence that forms the core structure of amyloid fibrils are known to impact on fibril assembly and stability but the effect of changes on noncore residues, particularly relating to functionalized fibrils where the fibril core is preserved, has not been systematically examined. In this study, the short peptide sequence TTR(105… CONTINUE READING