Noncoordinate regulation of epithelial Na channel and Na pump subunit mRNAs in kidney and colon by aldosterone.

@article{Escoubet1997NoncoordinateRO,
  title={Noncoordinate regulation of epithelial Na channel and Na pump subunit mRNAs in kidney and colon by aldosterone.},
  author={Brigitte Escoubet and Christiane Coureau and J. P. Bonvalet and Nicolette Farman},
  journal={The American journal of physiology},
  year={1997},
  volume={272 5 Pt 1},
  pages={C1482-91}
}
Distal colon and renal cortical collecting ducts are major effectors of aldosterone-dependent Na homeostasis. Na is absorbed by entry through an apical amiloride-sensitive Na channel and extruded by Na-K-ATPase at the basolateral membrane. Using a ribonuclease protection assay, we studied, in vivo, aldosterone regulation of alpha-, beta-, gamma-subunits of the rat epithelial Na channel (rENaC) and alpha 1- and beta 1-subunits of Na-K-ATPase. In the kidney, Na-K-ATPase mRNAs were also assayed… CONTINUE READING