Noncompetitive inhibition of glycylsarcosine transport by quinapril in rabbit renal brush border membrane vesicles: effect on high-affinity peptide transporter.

@article{Akarawut1998NoncompetitiveIO,
  title={Noncompetitive inhibition of glycylsarcosine transport by quinapril in rabbit renal brush border membrane vesicles: effect on high-affinity peptide transporter.},
  author={Wiyada Akarawut and Clara J Lin and David E Smith},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={287 2},
  pages={684-90}
}
Angiotensin converting enzyme (ACE) inhibitors are important therapeutic agents for treating patients with hypertension and cardiovascular diseases. Although most ACE inhibitors are cleared by the kidney via glomerular filtration and tubular secretion, little is known about their reabsorption potential. In particular, it is believed that while certain ACE inhibitors are transported by the intestinal peptide transporter (PepT1), these same compounds do not interact with the renal peptide… CONTINUE READING

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