Noncompetitive blocking of human GLUT1 hexose transporter by methylxanthines reveals an exofacial regulatory binding site.

@article{Ojeda2012NoncompetitiveBO,
  title={Noncompetitive blocking of human GLUT1 hexose transporter by methylxanthines reveals an exofacial regulatory binding site.},
  author={Paola G Ojeda and Alejandra P{\'e}rez and Lorena Ojeda and Mauricio Vargas-Uribe and Coralia I. Rivas and M{\'o}nica Salas and Juan Vera and Alejandro Monsalvo Reyes},
  journal={American journal of physiology. Cell physiology},
  year={2012},
  volume={303 5},
  pages={C530-9}
}
Glucose transporter (GLUT)1 has become an attractive target to block glucose uptake in malignant cells since most cancer cells overexpress GLUT1 and are sensitive to glucose deprivation. Methylxanthines are natural compounds that inhibit glucose uptake; however, the mechanism of inhibition remains unknown. Here, we used a combination of binding and glucose transport kinetic assays to analyze in detail the effects of caffeine, pentoxifylline, and theophylline on hexose transport in human… CONTINUE READING

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Here , we used a combination of binding and glucose transport kinetic assays to analyze in detail the effects of caffeine , pentoxifylline , and theophylline on hexose transport in human erythrocytes .
Here , we used a combination of binding and glucose transport kinetic assays to analyze in detail the effects of caffeine , pentoxifylline , and theophylline on hexose transport in human erythrocytes .
Here , we used a combination of binding and glucose transport kinetic assays to analyze in detail the effects of caffeine , pentoxifylline , and theophylline on hexose transport in human erythrocytes .
Here , we used a combination of binding and glucose transport kinetic assays to analyze in detail the effects of caffeine , pentoxifylline , and theophylline on hexose transport in human erythrocytes .
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