Noncompetitive antiestrogenic effect of RU 486 in blocking the estrogen-stimulated luteinizing hormone surge and the proliferative action of estradiol on endometrium in castrate monkeys.

@article{Wolf1989NoncompetitiveAE,
  title={Noncompetitive antiestrogenic effect of RU 486 in blocking the estrogen-stimulated luteinizing hormone surge and the proliferative action of estradiol on endometrium in castrate monkeys.},
  author={J P Wolf and Jeng Hsiu and T. L. Anderson and Andr{\'e} Ulmann and Etienne Emile Baulieu and Gary D. Hodgen},
  journal={Fertility and sterility},
  year={1989},
  volume={52 6},
  pages={1055-60}
}
The noncompetitive antiestrogenic effects of RU 486 were examined using estradiol (E2)-treated ovariectomized monkeys given RU 486, progesterone (P), or both. The E2-induced luteinizing-hormone (LH) surge of control animals was abrogated by P and/or RU 486. Secretory transformation by P was inhibited by RU 486 coadministration. RU 486 alone (1 mg/kg) induced endometrial secretory transformation, but higher doses (5 mg/kg) inhibited proliferation and secretory activity. Thus in the presence of P… CONTINUE READING