Noncompetitive N-methyl-D-aspartate antagonists affect multiple ionic currents.

  • Sheila Rothman
  • Published 1988 in
    The Journal of pharmacology and experimental…


Recent reports have indicated that the dissociative anesthetic ketamine and the related drugs phencyclidine and MK-801 noncompetitively antagonize excitation mediated by the N-methyl-D-aspartate receptor; they have little effect at kainate or quisqualate receptors. However, this action does not readily explain all the behavioral or metabolic effects of… (More)


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