Noncoding RNAs of Trithorax Response Elements Recruit Drosophila Ash1 to Ultrabithorax

@article{SanchezElsner2006NoncodingRO,
  title={Noncoding RNAs of Trithorax Response Elements Recruit Drosophila Ash1 to Ultrabithorax},
  author={Tilman Sanchez-Elsner and Dawei Gou and Elisabeth Kremmer and Frank Sauer},
  journal={Science},
  year={2006},
  volume={311},
  pages={1118 - 1123}
}
Homeotic genes contain cis-regulatory trithorax response elements (TREs) that are targeted by epigenetic activators and transcribed in a tissue-specific manner. We show that the transcripts of three TREs located in the Drosophila homeotic gene Ultrabithorax (Ubx) mediate transcription activation by recruiting the epigenetic regulator Ash1 to the template TREs. TRE transcription coincides with Ubx transcription and recruitment of Ash1 to TREs in Drosophila. The SET domain of Ash1 binds all three… 
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