Noncoding RNA transcription targets AID to divergently transcribed loci in B cells

@article{Pefanis2014NoncodingRT,
  title={Noncoding RNA transcription targets AID to divergently transcribed loci in B cells},
  author={Evangelos Pefanis and Jiguang Wang and Gerson Rothschild and Junghyun Lim and Jaime Chao and Raul Rabadan and Aris N. Economides and Uttiya Basu},
  journal={Nature},
  year={2014},
  volume={514},
  pages={389-393}
}
The vast majority of the mammalian genome has the potential to express noncoding RNA (ncRNA). The 11-subunit RNA exosome complex is the main source of cellular 3′–5′ exoribonucleolytic activity and potentially regulates the mammalian noncoding transcriptome. Here we generated a mouse model in which the essential subunit Exosc3 of the RNA exosome complex can… CONTINUE READING