Nonclinical safety assessment of Efinaconazole Solution (10%) for onychomycosis treatment.

  title={Nonclinical safety assessment of Efinaconazole Solution (10%) for onychomycosis treatment.},
  author={William Jo and Marian W. Glynn and Hiroaki Nejishima and Hisakazu Sanada and Kenji Minowa and Barry Calvarese and Hisato Senda and Radhakrishnan Pillai and Linda Mutter},
  journal={Regulatory toxicology and pharmacology : RTP},
  volume={70 1},
Efinaconazole is a triazole developed as a 10% solution for topical treatment of onychomycosis, a common fungal nail infection. Efinaconazole solution and topical formulation vehicle administered dermally to mice (13weeks), rats (6months) and minipigs (9months) produced transient erythema, minimal to modest hyperkeratosis, and mild microscopic skin inflammation. The liver was the target organ of systemic toxicity; reversible, minimal to moderate vacuolated changes were noted in the rat dermal… CONTINUE READING


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