Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates.

Abstract

The dopamine transporter (DAT) is a sodium-coupled symporter protein responsible for modulating the concentration of extraneuronal dopamine in the brain. The DAT is a principle target of various psychostimulant, nootropic, and antidepressant drugs, as well as certain drugs used recreationally, including the notoriously addictive stimulant cocaine. DAT… (More)
DOI: 10.1124/jpet.111.191056

Topics

3 Figures and Tables

Cite this paper

@article{Schmitt2013NonclassicalPO, title={Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates.}, author={Kyle C. Schmitt and Richard B. Rothman and Maarten E. A. Reith}, journal={The Journal of pharmacology and experimental therapeutics}, year={2013}, volume={346 1}, pages={2-10} }