Noncholinesterase Effects Induced by Organophosphate Pesticides and their Relationship to Cognitive Processes: Implication for the Action of Acylpeptide Hydrolase

@article{Pancetti2007NoncholinesteraseEI,
  title={Noncholinesterase Effects Induced by Organophosphate Pesticides and their Relationship to Cognitive Processes: Implication for the Action of Acylpeptide Hydrolase},
  author={Floria Pancetti and Cristina Olmos and Alexies Dagnino-Subiabre and Carlos Rozas and Bernardo Morales},
  journal={Journal of Toxicology and Environmental Health, Part B},
  year={2007},
  volume={10},
  pages={623 - 630}
}
Organophosphate pesticides have been classically described as inhibitors of acetylcholinesterase (AChE) activity in insects and invertebrates. However, there is now more evidence supporting the hypothesis that these compounds also act through noncholinergic pathways, especially those related to cognitive processes. The enzyme acylpeptide hydrolase was identified as a new target for organophosphate pesticides. This enzyme is more sensitive than AChE to some organophosphates (OP), including… 
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Low level chlorpyrifos exposure increases anandamide accumulation in juvenile rat brain in the absence of brain cholinesterase inhibition.
Chlorpyrifos-, diisopropylphosphorofluoridate-, and parathion-induced behavioral and oxidative stress effects: are they mediated by analogous mechanisms of action?
TLDR
Novel data is provided on the relationship between cognitive alterations and oxidative stress, and the diverse mechanisms of action along a temporal axis in response to OP exposures in the rat.
Chronic dietary exposure to chlorpyrifos causes behavioral impairments, low activity of brain membrane-bound acetylcholinesterase, and increased brain acetylcholinesterase-R mRNA.
Quantitative Structure–Activity Relationships for Organophosphates Binding to Trypsin and Chymotrypsin
TLDR
These models are highly predictive and capable of delineating the complex mechanism of action between OP and serine proteases, and ultimately, by applying this approach to other OP enzyme reactions such as AChE, facilitate the development of biologically based dose-response models.
Protein adducts as biomarkers of exposure to organophosphorus compounds.
Structure dependent determination of organophosphate targets in mammalian tissues using activity-based protein profiling.
TLDR
A series of probes for activity-based protein profiling (ABPP) featuring two distinct reactive groups that mimic OP chemical reactivity can be used to assess reactivation of OP-inhibited enzymes by N-oximes and may serve as diagnostic tools for screening of therapeutic candidates in a panel of protein targets.
Association between cholinesterase's inhibition and cognitive impairment: A basis for prevention policies of environmental pollution by organophosphate and carbamate pesticides in Chile.
Two cholinesterase inhibitors trigger dissimilar effects on behavior and body weight in C57BL/6 mice: The case of chlorpyrifos and rivastigmine
Comparative study on short- and long-term behavioral consequences of organophosphate exposure: relationship to AChE mRNA expression.
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