Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo.

@article{Caserta2015NoncatalyticPM,
  title={Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo.},
  author={Enrico Caserta and Onur Egriboz and Hui Wang and Chelsea K Martin and Christopher Koivisto and Thierry P{\'e}cot and Raleigh D. Kladney and Changxian Shen and Kang-Sup Shim and Thac Pham and Matthew K Karikomi and Melissa J Mauntel and Sarmila Majumder and Mar{\'i}a Cecilia Cuiti{\~n}o and Xing Lian Tang and Arunima Srivastava and Lianbo Yu and Julie A. Wallace and Xiaokui Molly Mo and Morag Park and Soledad A. Fernandez and Robert T. Pilarski and Krista M D La Perle and Thomas J. Rosol and Vincenzo Coppola and Diego Hern{\'a}n Gonz{\'a}lez Castrill{\'o}n and Cynthia Dawn Timmers and David E. Cohn and David M O'malley and Floor J. Backes and A. J. Alvarez-Morujo Su{\'a}rez and Paul J Goodfellow and Helen M. Chamberlin and Erin R. Macrae and Charles L. Shapiro and Michael C. Ostrowski and Gustavo W Leone},
  journal={Genes & development},
  year={2015},
  volume={29 16},
  pages={
          1707-20
        }
}
Inactivation of phosphatase and tensin homology deleted on chromosome 10 (PTEN) is linked to increased PI3K-AKT signaling, enhanced organismal growth, and cancer development. Here we generated and analyzed Pten knock-in mice harboring a C2 domain missense mutation at phenylalanine 341 (Pten(FV)), found in human cancer. Despite having reduced levels of PTEN protein, homozygous Pten(FV/FV) embryos have intact AKT signaling, develop normally, and are carried to term. Heterozygous Pten(FV/+) mice… CONTINUE READING
BETA
2
Twitter Mentions

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Regulation of PTEN expression by noncoding RNAs

  • Journal of experimental & clinical cancer research : CR
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND