Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.

@article{Knodler2014NoncanonicalIA,
  title={Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.},
  author={Leigh A Knodler and Shauna M. Crowley and Ho Pan Sham and H H Clarice Yang and Marie Wrande and C. C. H. Ma and Robert K Ernst and Olivia Steele-Mortimer and Jean Celli and Bruce A Vallance},
  journal={Cell host & microbe},
  year={2014},
  volume={16 2},
  pages={249-256}
}
Inflammasome-mediated host defenses have been extensively studied in innate immune cells. Whether inflammasomes function for innate defense in intestinal epithelial cells, which represent the first line of defense against enteric pathogens, remains unknown. We observed enhanced Salmonella enterica serovar Typhimurium colonization in the intestinal epithelium of caspase-11-deficient mice, but not at systemic sites. In polarized epithelial monolayers, siRNA-mediated depletion of caspase-4, a… CONTINUE READING
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