Noncanonical functions of aminoacyl-tRNA synthetases

@article{Smirnova2012NoncanonicalFO,
  title={Noncanonical functions of aminoacyl-tRNA synthetases},
  author={Ekaterina V. Smirnova and Valentina A. Lakunina and Ivan Tarassov and I. Krasheninnikov and Piotr Kamenski},
  journal={Biochemistry (Moscow)},
  year={2012},
  volume={77},
  pages={15-25}
}
Aminoacyl-tRNA synthetases, together with their main function of covalent binding of an amino acid to a corresponding tRNA, also perform many other functions. They take part in regulation of gene transcription, apoptosis, translation, and RNA splicing. Some of them function as cytokines or catalyze different reactions in living cells. Noncanonical functions can be mediated by additional domains of these proteins. On the other hand, some of the noncanonical functions are directly associated with… CONTINUE READING
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