Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration.

@article{Toyama2010NoncanonicalWI,
  title={Noncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migration.},
  author={Takashi Toyama and Han Chu Lee and Hironori Koga and Jack R Wands and Mi Ran Kim},
  journal={Molecular cancer research : MCR},
  year={2010},
  volume={8 2},
  pages={
          254-65
        }
}
The canonical Wnt signaling is frequently activated due to overexpression and/or mutations in components of this pathway in hepatocellular carcinoma (HCC). However, the biological role of noncanonical Wnt-mediated signaling in HCC with respect to the signaling pathways involved and their physiologic function is unknown. Here, we report the role of Wnt11, a member of the noncanonical cascade, in hepatic oncogenesis. The expression levels of Wnt11 mRNA and protein were significantly downregulated… CONTINUE READING

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