Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation.

  title={Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation.},
  author={Xiaolin Tu and Kyu Sang Joeng and Keiichi I Nakayama and Jayaraj Rajagopal and Thomas J Carroll and Andrew P. McMahon and Fanxin Long},
  journal={Developmental cell},
  volume={12 1},
Wnt signaling regulates a variety of developmental processes in animals. Although the beta-catenin-dependent (canonical) pathway is known to control cell fate, a similar role for noncanonical Wnt signaling has not been established in mammals. Moreover, the intracellular cascades for noncanonical Wnt signaling remain to be elucidated. Here, we delineate a pathway in which Wnt3a signals through the Galpha(q/11) subunits of G proteins to activate phosphatidylinositol signaling and PKCdelta in the… CONTINUE READING
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