Noncanonical Wnt signaling promotes apoptosis in thymocyte development

  title={Noncanonical Wnt signaling promotes apoptosis in thymocyte development},
  author={Huiling Liang and Andrew H. Coles and Zhiqing Zhu and Jennifer Zayas and Roland Jurecic and Joonsoo Kang and Stephen N. Jones},
  journal={The Journal of Experimental Medicine},
  pages={3077 - 3084}
The Wnt-beta-catenin signaling pathway has been shown to govern T cell development by regulating the growth and survival of progenitor T cells and immature thymocytes. We explore the role of noncanonical, Wnt-Ca(2+) signaling in fetal T cell development by analyzing mice deficient for Wnt5a. Our findings reveal that Wnt5a produced in the thymic stromal epithelium does not alter the development of progenitor thymocytes, but regulates the survival of alphabeta lineage thymocytes. Loss of Wnt5a… CONTINUE READING


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