Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK.

@article{Chang2007NoncanonicalWS,
  title={Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK.},
  author={Jia Yuan Chang and Wataru Sonoyama and Zhihua Wang and Qiming Jin and Chengfei Zhang and Paul H Krebsbach and William V Giannobile and Songtao Shi and Cun-yu Wang},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 42},
  pages={
          30938-48
        }
}
Mesenchymal stem cells (MSCs) are multipotent cells that can be differentiated into osteoblasts and provide an excellent cell source for bone regeneration and repair. Recently, the canonical Wnt/beta-catenin signaling pathway has been found to play a critical role in skeletal development and osteogenesis, implying that Wnts can be utilized to improve de novo bone formation mediated by MSCs. However, it is unknown whether noncanonical Wnt signaling regulates osteogenic differentiation. Here, we… CONTINUE READING
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