Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis.

@article{Maurus2005NoncanonicalWS,
  title={Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis.},
  author={Daniel Maurus and Christophe H{\'e}ligon and Anja B{\"u}rger-Schw{\"a}rzler and Andr{\'e} W. Br{\"a}ndli and Michael K{\"u}hl},
  journal={The EMBO journal},
  year={2005},
  volume={24 6},
  pages={1181-91}
}
Wnt-4 is expressed in developing neural and renal tissue and is required for renal tubulogenesis in mouse and Xenopus. The function of Wnt-4 in neural differentiation is unknown so far. Here we demonstrate that Wnt-4 is required for eye development in Xenopus laevis. This effect of Wnt-4 depends on the activation of a beta-catenin-independent, noncanonical… CONTINUE READING