Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis.

  title={Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis.},
  author={Shinong Wang and Mark C. Wilkes and Edward B. Leof and Raimund R Hirschberg},
  journal={American journal of physiology. Renal physiology},
  volume={298 1},
Renal interstitial fibrosis is a major determinant of renal failure in the majority of chronic renal diseases. Transforming growth factor-beta (TGF-beta) is the single most important cytokine promoting renal fibrogenesis. Recent in vitro studies identified novel non-smad TGF-beta targets including p21-activated kinase-2 (PAK2), the abelson nonreceptor tyrosine kinase (c-Abl), and the mammalian target of rapamycin (mTOR) that are activated by TGF-beta in mesenchymal cells, specifically in… CONTINUE READING


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