Noncanonical Roles of Voltage-Gated Sodium Channels

@article{Black2013NoncanonicalRO,
  title={Noncanonical Roles of Voltage-Gated Sodium Channels},
  author={Joel A. Black and Stephen G. Waxman},
  journal={Neuron},
  year={2013},
  volume={80},
  pages={280-291}
}
The Hodgkin-Huxley formulation, at its 60th anniversary, remains a bastion of neuroscience. Sodium channels Nav1.1-Nav1.3 and Nav1.6-Nav1.9 support electrogenesis in neurons and are often considered "neuronal," whereas Nav1.4 and Nav1.5 drive electrogenesis in skeletal and cardiac muscle. These channels are, however, expressed in cell types that are not considered electrically excitable. Here, we discuss sodium channel expression in diverse nonexcitable cell types, including astrocytes, NG2… CONTINUE READING
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