Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms

  title={Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms},
  author={Petr Broz and Denise M Monack},
  booktitle={PLoS pathogens},
Inflammasomes are cytosolic, multiprotein complexes assembled by members of the NOD-like receptor (NLR) and PYHIN protein families in response to pathogen-associated molecular patterns (PAMPs) and danger signals, and serve as activation platforms for caspase-1. Recently, a new noncanonical inflammasome pathway has been described that activates caspase-11, an understudied pro-inflammatory caspase. Despite new insights into the signaling events that control caspase-11 activation, a number of… CONTINUE READING
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