Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicators.

@article{Ellinger2008NoncancerousPD,
  title={Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicators.},
  author={J{\"o}rg Ellinger and Patrick Jan Bastian and Kim I Haan and Lukas Heukamp and Reinhard Mechoulam Raphael Buettner and Rolf Fimmers and Stefan Cajetan M{\"u}ller and Alexander A. von R{\"u}cker},
  journal={International journal of cancer},
  year={2008},
  volume={122 1},
  pages={
          138-43
        }
}
Our study was designed to evaluate Cell-Free DNA in sera of prostate cancer (PCA) patients as a useful biomarker. Real-time PCR was used to amplify a <200 bp PTGS2 DNA fragment that biochemically characterizes apoptosis and a larger >250 bp Reprimo DNA fragment that defines mostly other cell death entities. The apoptosis index (AI) expresses the ratio of PTGS2 to Reprimo DNA fragments. GSTP1 hypermethylation was assessed to evaluate the amount of tumor-derived DNA. We analyzed serum of 216… CONTINUE READING
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