Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency.

@article{Zuhorn2005NonbilayerPO,
  title={Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency.},
  author={Inge S. Zuhorn and Udo Bakowsky and Evgeny Polushkin and W. Hester Visser and Marc C A Stuart and Jan B. F. N. Engberts and Dick Hoekstra},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2005},
  volume={11 5},
  pages={801-10}
}
Cationic lipids are widely used for gene delivery, and inclusion of dioleoylphosphatidylethanolamine (DOPE) as a helper lipid in cationic lipid-DNA formulations often promotes transfection efficacy. To investigate the significance of DOPE's preference to adopt a hexagonal phase in the mechanism of transfection, the properties and transfection efficiencies of SAINT-2/DOPE lipoplexes were compared to those of lipoplexes containing lamellar-phase-forming dipalmitoylphosphatidylethanolamine (DPPE… CONTINUE READING

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