Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-2/6 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus

@inproceedings{WongBaeza2015NonbilayerPA,
  title={Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-2/6 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus},
  author={Carlos Wong-Baeza and Alonso Tescucano and Horacio Astudillo and Albany Res{\'e}ndiz and Carla Landa and Luis Espa{\~n}a and Jeanet Seraf{\'i}n-L{\'o}pez and I C E Estrada-Garcia and Sergio Estrada-Parra and Leopoldo Flores-Romo and Carlos Wong and Isabel Baeza},
  booktitle={Journal of immunology research},
  year={2015}
}
Systemic lupus erythematosus is characterized by dysregulated activation of T and B cells and autoantibodies to nuclear antigens and, in some cases, lipid antigens. Liposomes with nonbilayer phospholipid arrangements induce a disease resembling human lupus in mice, including IgM and IgG antibodies against nonbilayer phospholipid arrangements. As the effect of these liposomes on the innate immune response is unknown and innate immune system activation is necessary for efficient antibody… CONTINUE READING
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