Nonbiased Molecular Screening Identifies Novel Molecular Regulators of Fibrogenic and Proliferative Signaling in Myxomatous Mitral Valve Disease.

@article{Thalji2015NonbiasedMS,
  title={Nonbiased Molecular Screening Identifies Novel Molecular Regulators of Fibrogenic and Proliferative Signaling in Myxomatous Mitral Valve Disease.},
  author={Nassir M A Thalji and Michael A Hagler and Heyu Zhang and Grace C Casaclang-Verzosa and Asha A. Nair and Rakesh M. Suri and Jordan D. Miller},
  journal={Circulation. Cardiovascular genetics},
  year={2015},
  volume={8 3},
  pages={516-28}
}
BACKGROUND Pathological processes underlying myxomatous mitral valve degeneration (MMVD) remain poorly understood. We sought to identify novel mechanisms contributing to the development of this condition. METHODS AND RESULTS Microarrays were used to measure gene expression in 11 myxomatous and 11 nonmyxomatous human mitral valves. Differential gene expression (thresholds P<0.05; fold-change >1.5) and pathway activation (Ingenuity) were confirmed using quantitative reverse transcriptase… CONTINUE READING

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