Nonaqueous capillary electrophoresis-mass spectrometry for separation of venlafaxine and its phase I metabolites.

@article{Cherkaoui2001NonaqueousCE,
  title={Nonaqueous capillary electrophoresis-mass spectrometry for separation of venlafaxine and its phase I metabolites.},
  author={Samir Cherkaoui and Serge L. Rudaz and Jean Luc Veuthey},
  journal={Electrophoresis},
  year={2001},
  volume={22 3},
  pages={
          491-6
        }
}
Aqueous and nonaqueous capillary electrophoresis (NACE) were investigated for separation of venlafaxine, a new second-generation antidepressant, and its three phase I metabolites. Working at basic pH, around the venlafaxine pKa value, was effective in resolving the investigated drugs, but created considerable peak tailing. To overcome electrostatic interactions between analytes and silanol groups, investigations were also carried out at acidic pH. However, despite the addition of up to 50% v/v… CONTINUE READING