Nonanticoagulant heparin inhibits NF-kappaB activation and attenuates myocardial reperfusion injury.

@article{Thourani2000NonanticoagulantHI,
  title={Nonanticoagulant heparin inhibits NF-kappaB activation and attenuates myocardial reperfusion injury.},
  author={Vinod H. Thourani and Somjot S. Brar and Thomas P Kennedy and Lisa R Thornton and John Albert Watts and Russell S Ronson and Zuowei Zhao and Anne Sturrock and John R. Hoidal and Jakob Vinten-Johansen},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={278 6},
  pages={H2084-93}
}
Heparin reduces ischemia-reperfusion injury to myocardium. This effect has been attributed to complement inhibition, but heparin also has other activities that might diminish ischemia-reperfusion. To further probe these mechanisms, we compared heparin or an o-desulfated nonanticoagulant heparin with greatly reduced anticomplement activity. When given at the time of coronary artery reperfusion in a canine model of myocardial infarction, heparin or o-desulfated heparin equally reduced neutrophil… CONTINUE READING
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