Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells*

@article{Badal2015NonantibioticEO,
  title={Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells*},
  author={Sujan Badal and Yeng F. Her and L. J. Maher},
  journal={The Journal of Biological Chemistry},
  year={2015},
  volume={290},
  pages={22287 - 22297}
}
Background: Fe(II)-dependent dioxygenases regulate epigenetic control, collagen maturation, and HIF degradation. Results: Iron chelation by fluoroquinolone antibiotics results in DNA and histone hypermethylation, suppression of collagen prolyl hydroxylation, and inhibition of HIF mRNA translation. Conclusion: Dioxygenase inhibition may explain renal toxicity and tendinopathy side effects of fluoroquinolones. Significance: This study suggests mechanisms for obscure fluoroquinolone-associated… Expand
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  • 4
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References

SHOWING 1-10 OF 87 REFERENCES
The fluoroquinolones
  • 71
Fluoroquinolone toxicity profiles: a review focusing on newer agents.
  • Benjamin A Lipsky, C. Baker
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1999
  • 337
  • PDF
Toxicity of Quinolones
  • 98
Effects of difloxacin on the metabolism of glycosaminoglycans and collagen in organ cultures of articular cartilage.
  • 33
Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor*
  • 679
  • PDF
Emerging mechanisms of fluoroquinolone resistance.
  • D. Hooper
  • Biology, Medicine
  • Emerging infectious diseases
  • 2001
  • 565
  • PDF
...
1
2
3
4
5
...