Nonamer binding protein induces a bend in the immunoglobulin gene recombinational signal sequence.


DNA bending has been shown to play a critical role in conservative site-specific DNA recombination reactions such as lambda integration. V(D)J recombination, the only mammalian site directed recombination system, is directed by recombinational signal sequences composed of heptamer, nonamer and spacer elements. The nonamer element, GGTTTTTGT, is similar to… (More)