Nonalcoholic fatty liver disease is associated with increased GHBP and reduced GH/IGF-I levels.

@article{Fusco2012NonalcoholicFL,
  title={Nonalcoholic fatty liver disease is associated with increased GHBP and reduced GH/IGF-I levels.},
  author={Alessandra Fusco and Luca Miele and Annalisa D'Uonnolo and Alessandra Forgione and Laura Riccardi and Consuelo Cefalo and Angela Barini and Antonio Bianchi and A Giampietro and Vincenzo Cimino and Raffaele Landolfi and Antonio Grieco and Laura de Marinis},
  journal={Clinical endocrinology},
  year={2012},
  volume={77 4},
  pages={531-6}
}
INTRODUCTION Nonalcoholic fatty liver disease (NAFLD) has been described in adult GH deficiency syndrome. Furthermore, chronic liver disease can be associated with significant changes in levels of IGF-I, GH-binding protein (GHBP), IGF-binding proteins (IGFBPs) and acid-labile subunit (ALS). However, the effect of liver steatosis on the GHBP production has not been investigated yet. AIM OF THE STUDY To explore whether GH secretion and/or levels of IGF-I, IGFBP-3, ALS and GHBP could be altered… CONTINUE READING