Nonalcoholic fatty liver disease in HIV-infected patients referred to a metabolic clinic: prevalence, characteristics, and predictors.

@article{Guaraldi2008NonalcoholicFL,
  title={Nonalcoholic fatty liver disease in HIV-infected patients referred to a metabolic clinic: prevalence, characteristics, and predictors.},
  author={Giovanni Guaraldi and Nicola Squillace and Chiara Stentarelli and Gabriella Orlando and Roberto D'amico and Guido Ligabue and Federica Fiocchi and Stefano Zona and Paola Loria and Roberto Esp{\'o}sito and Frank J Palella},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2008},
  volume={47 2},
  pages={
          250-7
        }
}
  • G. Guaraldi, N. Squillace, +8 authors F. Palella
  • Published 15 July 2008
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
BACKGROUND The prevalence and predictors of nonalcoholic fatty liver disease (NAFLD) in human immunodeficiency virus (HIV)-infected highly active antiretroviral therapy-experienced patients and the association of NAFLD with risk of cardiovascular disease and subclinical atherosclerosis are unknown. METHODS We performed a cross-sectional observational study. NAFLD was defined by liver-spleen attenuation values of <1.1 on computed tomography in persons who had neither evidence of chronic viral… 
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Highly Influential Citations
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Nonalcoholic fatty liver disease diagnosed by transient elastography with controlled attenuation parameter in unselected HIV monoinfected patients
TLDR
NAFLD and significant liver fibrosis diagnosed by transient elastography with CAP are major comorbidities in unselected HIV monoinfected persons on antiretroviral therapy, particularly if metabolic conditions and elevated ALT coexist.
Nonalcoholic Fatty Liver Disease Among Individuals with HIV Mono-infection: A Growing Concern?
TLDR
Clinicians should be aware of the risk of nonalcoholic fatty liver disease in patients with HIV and consider using TE for NAFLD diagnosis and surveillance, and there is a paucity of evidence in this population, transient elastography (TE) appears to provide a sensitive, non-invasive screening modality.
Traditional but Not HIV-Related Factors Are Associated with Nonalcoholic Fatty Liver Disease in Asian Patients with HIV-1 Infection
TLDR
The incidence of NALFD among Asian patients with HIV-1 infection is similar to that in Western countries, and NAFLD was associated with high BMI, dyslipidemia, and high ALT/AST ratio, but not with HIV -related factors.
Prevalence, Predictors, and Severity of Lean Nonalcoholic Fatty Liver Disease in Patients Living With Human Immunodeficiency Virus
TLDR
Investigations for NAFLD should be proposed in older patients with dyslipidemia and elevated ALT, even if normoweight; however, it can occur in normow eight (lean) patients.
Nonalcoholic fatty liver disease and hepatic fibrosis among perinatally HIV-monoinfected Asian adolescents receiving antiretroviral therapy
TLDR
Among perinatally HIV-monoinfected Asian adolescents with history of elevated aminotransferase enzymes, persistent hepatic abnormalities are not uncommon and Screening for liver complications by noninvasive diagnostic tools might be considered in at risk individuals.
Prevalence and predictors of liver steatosis and fibrosis in unselected patients with HIV mono-infection.
Validation of the Liver Fat Score in Human Immunode fi ciency Virus Patients With Nonalcoholic Fatty Liver
TLDR
A singlecenter retrospective study to validate the abilities of the liver fat score (LFS) and the lipid accumulation product (LAP) to detect hepatic steatosis in HIV-positive patients, compared with HIV-negative individuals (controls).
Nonalcoholic fatty liver disease and steatohepatitis in people living with HIV
TLDR
The prevalence and progression of NAFLD in human immunodeficiency virus (HIV) infection are reported to be widely variable and larger and more effective studies are needed to evaluate the effects of NASH in PLWH and its progression.
A gathering storm: HIV infection and nonalcoholic fatty liver disease in low and middle-income countries
TLDR
The cohort data onNAFLD in HIV is reviewed, the risk factors, pathogenesis of hepatic steatosis, NAFLD and nonalcoholic steatohepatitis are discussed, diagnostic approaches and therapeutic options available for NAFLd in the setting of HIV, and the specific challenges of NAFLDs in HIV for LMICs are discussed.
Prevalence, predictors and severity of lean non-alcoholic fatty liver disease in HIV-infected patients.
  • A. Cervo, J. Milic, +8 authors G. Sebastiani
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2020
TLDR
Investigations for NAFLD should be proposed in older patients with dyslipidemia and elevated ALT even if normoweight, as it affects one in four lean HIV mono-infected patients.
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