Nonalcoholic fatty liver disease: current concepts, epidemiology and management strategies

  title={Nonalcoholic fatty liver disease: current concepts, epidemiology and management strategies},
  author={Dunya Tomic and William Kemp and Stuart K. Roberts},
  journal={European Journal of Gastroenterology \& Hepatology},
Nonalcoholic fatty liver disease (NAFLD) is now the most prevalent liver disease in the world. It involves a spectrum of conditions from hepatic steatosis to nonalcoholic steatohepatitis and liver fibrosis, and is a major cause of cirrhosis and hepatocellular carcinoma. It is defined by presence of steatosis in 5% of hepatocytes or more in the absence of other causes of fatty liver. The metabolic syndrome is the major known risk factor for NAFLD. Dietary contributors such as high fructose… 

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An overview of the main lipids involved in the pathogenesis of non-alcoholic fatty liver disease is presented and their association with lipotoxicity, insulin resistance, oxidative stress and other processes responsible for its progression are summarized.

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Diagnosis and therapy of nonalcoholic steatohepatitis.

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Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease

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