Nonadherence to treatment causing acute hospitalizations in people with epilepsy: an observational, prospective study.

@article{Samsonsen2014NonadherenceTT,
  title={Nonadherence to treatment causing acute hospitalizations in people with epilepsy: an observational, prospective study.},
  author={Christian Samsonsen and Arne C. Reimers and Geir Br{\aa}then and Grethe Helde and Eylert Brodtkorb},
  journal={Epilepsia},
  year={2014},
  volume={55 11},
  pages={
          e125-8
        }
}
The aim was to assess the clinical relevance of antiepileptic drug (AED) nonadherence by means of therapeutic drug concentration monitoring (TDM). Two hundred eighty-two consecutive patients with epilepsy acutely admitted to hospital for seizures were included. Nonadherence was defined as having a serum concentration/dose ratio at admission of <75% of the patient's own control value (probable nonadherence: 50-75%; definite: <50%). Nonadherence was identified in 39% of patients (definite 24… CONTINUE READING
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