Nonactivated microglia promote oligodendrocyte precursor survival and maturation through the transcription factor NF-kappa B.

@article{Nicholas2001NonactivatedMP,
  title={Nonactivated microglia promote oligodendrocyte precursor survival and maturation through the transcription factor NF-kappa B.},
  author={Richard Nicholas and Mark G. Wing and Alastair D Compston},
  journal={The European journal of neuroscience},
  year={2001},
  volume={13 5},
  pages={959-67}
}
We demonstrate a role for nonactivated rat microglia in the survival and maturation of oligodendrocyte precursor cells (OPCs). Media conditioned by nonactivated microglia increase the number of surviving galactocerebroside(+) (GalC(+)) oligodendrocytes in vitro at 48 h by inhibiting the apoptosis of OPCs and stimulating their maturation to GalC+ oligodendrocytes. These effects are not observed with medium conditioned by microglia activated with interferon-gamma (IFN-gamma). Conditioned medium… CONTINUE READING
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