Non-xanthine heterocycles: activity as antagonists of A1- and A2-adenosine receptors.

@article{Daly1988NonxanthineHA,
  title={Non-xanthine heterocycles: activity as antagonists of A1- and A2-adenosine receptors.},
  author={J. Daly and O. Hong and W. Padgett and M. Shamim and K. Jacobson and D. Ukena},
  journal={Biochemical pharmacology},
  year={1988},
  volume={37 4},
  pages={
          655-64
        }
}
  • J. Daly, O. Hong, +3 authors D. Ukena
  • Published 1988
  • Chemistry, Medicine
  • Biochemical pharmacology
  • A variety of non-xanthine heterocycles were found to be antagonists of binding of [3H]phenylisopropyladenosine to rat brain A1-adenosine receptors and of activation of adenylate cyclase via interaction of N-ethylcarboxamidoadenosine with A2-adenosine receptors in human platelet and rat phenochromocytoma cell membranes. The pyrazolopyridines tracazolate, cartazolate and etazolate were several fold more potent than theophylline at both A1- and A2-adenosine receptors. The pyrazolopyridines… CONTINUE READING
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