Non-weight bearing-induced muscle weakness: the role of myosin quantity and quality in MHC type II fibers.

@article{Kim2014NonweightBM,
  title={Non-weight bearing-induced muscle weakness: the role of myosin quantity and quality in MHC type II fibers.},
  author={Jong-Hee Kim and Ladora V Thompson},
  journal={American journal of physiology. Cell physiology},
  year={2014},
  volume={307 2},
  pages={C190-4}
}
We tested the hypothesis that non-weight bearing-induced muscle weakness (i.e., specific force) results from decreases in myosin protein quantity (i.e., myosin content per half-sarcomere and the ratio of myosin to actin) and quality (i.e., force per half-sarcomere and population of myosin heads in the strong-binding state during muscle contraction) in single myosin heavy chain (MHC) type II fibers. Fisher-344 rats were assigned to weight-bearing control (Con) or non-weight bearing (NWB). The… CONTINUE READING