Non-vitamin-K oral anticoagulants (NOACs) for the prevention of secondary stroke

@article{Diener2018NonvitaminKOA,
  title={Non-vitamin-K oral anticoagulants (NOACs) for the prevention of secondary stroke},
  author={Hans Christoph Diener and George Ntaios and Martin O’Donnell and J. Donald Easton},
  journal={Expert Opinion on Pharmacotherapy},
  year={2018},
  volume={19},
  pages={1597 - 1602}
}
ABSTRACT Introduction: In patients with atrial fibrillation (AF), oral anticoagulation with vitamin K antagonists (VKA) (warfarin, phenprocoumon) is effective both for primary and secondary stroke prevention with a 60–70% relative reduction in stroke risk compared with placebo. Mortality is reduced by 26%. VKA have a number of well-documented shortcomings which were overcome by non-vitamin-K oral anticoagulants (NOACs). Areas covered: Results of randomized trials for four NOACs (apixaban… 
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15 Citations
Background Citations
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Methods Citations
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15 Citations

Non-vitamin K oral anticoagulants for secondary stroke prevention in patients with atrial fibrillation
TLDR
The four NOACs had broadly similar efficacy for the major outcomes in secondary stroke prevention and two large trials tested the hypothesis that NOacs are more effective than 100 mg aspirin in patients with ESUS showed a significant benefit of the NOAC over aspirin.
Stroke prevention in atrial fibrillation : update with NOAC treatment and the impact of reversal
TLDR
Results from RCTs and real-world analyses consistently demonstrate the safety and efficacy profiles of dabigatran in patients with atrial fibrillation and Idarucizumab has been established as an effective reversal agent for dabig atran-treated patients and can be administered promptly and safely in a mobile, pre-hospital setting.
Rationale, Design and Methods of the Prospective Record of the Use of Dabigatran in Patients with Acute Stroke or TIA (PRODAST) Study
TLDR
The PRODAST study will provide important real-world data on safety and efficacy of antithrombotic therapy after acute stroke and TIA in patients with AF and compare the three-month rates of major haemorrhagic events between early versus late administration of dabigatran or treatment with vitamin-K antagonists.
Anticoagulant Selection in Relation to SAMe-TT2R2 Score in Patients with Atrial Fibrillation: The GLORIA-AF Registry.
Economy- and Social-Based Strategies for Anticoagulation of Patients with Atrial Fibrillation.
TLDR
Evaluating the costs related to anticoagulant therapy in a one-year period and the quality of life of atrial fibrillation patients treated in a public university hospital concluded that a nearly 40% reduction in the price of DOACs could make it feasible to incorporate these drugs into the Brazilian public health system.
Expert Consensus Statement for the Management of Patients with Embolic Stroke of Undetermined Source and Patent Foramen Ovale: a clinical guide by the Working Group for Stroke of the Hellenic Society of Cardiology and the Hellenic Stroke Organization.
Estimation of the economic burden of atrial fibrillation-related stroke in Greece
TLDR
It seems that ensuring efficient reallocation of resources in appropriate prevention and early intervention strategies could decrease AF-related stroke’s burden but also enhance healthcare systems’ efficiency.
Stroke: Insights into Thromboembolism Treatment and Prevention through the Decades.
TLDR
With the availability of back issues online for Thrombosis & Haemostasis ever since the original first published issue in 1957, it was felt that stroke could be an initial special focus, given the publication on this topic in Volume1, Issue1 of this journal.
Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery.
TLDR
Detailed structure-activity relationship studies using a C-ring-truncated version of Vorapaxar culminated in the discovery of three leads, represented as 13, 14, and 23, which possessed favorable pharmacokinetic properties and an off-target profile.
Conservative management of massive rivaroxaban overdose: A case report and literature review
In the cases of acute rivaroxaban overdose, conservative management without prothrombin complex concentrate or other coagulation factors may be sufficient if renal function is normal and there is no…
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