Non-visual GRKs: are we seeing the whole picture?

  title={Non-visual GRKs: are we seeing the whole picture?},
  author={J M Willets and R. A. John Challiss and Stefan R. Nahorski},
  journal={Trends in pharmacological sciences},
  volume={24 12},
G-protein-coupled receptor kinases (GRKs) comprise a family of seven mammalian serine/threonine protein kinases that phosphorylate and regulate agonist-occupied or constitutively active G-protein-coupled receptors (GPCRs). Studies of the details and consequences of these mechanisms have focused heavily on the original beta-adrenoceptor kinase (beta-ARK) family (GRK2 and GRK3) and, in particular, on phosphorylation-dependent recruitment of adaptor proteins such as the beta-arrestins. However… CONTINUE READING
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