Non-viral vectors for gene-based therapy

@article{Yin2014NonviralVF,
  title={Non-viral vectors for gene-based therapy},
  author={Hao Yin and Rosemary Lynn Kanasty and Ahmed A. Eltoukhy and Arturo J. Vegas and Joseph R. Dorkin and Daniel G. Anderson},
  journal={Nature Reviews Genetics},
  year={2014},
  volume={15},
  pages={541-555}
}
Gene-based therapy is the intentional modulation of gene expression in specific cells to treat pathological conditions. This modulation is accomplished by introducing exogenous nucleic acids such as DNA, mRNA, small interfering RNA (siRNA), microRNA (miRNA) or antisense oligonucleotides. Given the large size and the negative charge of these macromolecules, their delivery is typically mediated by carriers or vectors. In this Review, we introduce the biological barriers to gene delivery in vivo… 

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