Non-viral nanosystems for systemic siRNA delivery.

  title={Non-viral nanosystems for systemic siRNA delivery.},
  author={St{\'e}phanie David and Bruno Pitard and J F Benoit and Catherine Passirani},
  journal={Pharmacological research},
  volume={62 2},
To use siRNA (small interfering ribonucleic acids) for systemic administration, a delivery system is often necessary to overcome barriers between administration and the target sites. These delivery systems require different properties to be efficient. On the one hand, they have to protect siRNA from degradation and/or inactivation and, on the other hand, they have themselves to be stable in blood and possess stealth properties to avoid elimination and degradation. Active and/or passive… CONTINUE READING
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