Non-viral gene delivery in skeletal muscle: a protein factory

@article{Lu2003NonviralGD,
  title={Non-viral gene delivery in skeletal muscle: a protein factory},
  author={Qi Long Lu and George Bou-Gharios and Terence A. Partridge},
  journal={Gene Therapy},
  year={2003},
  volume={10},
  pages={131-142}
}
Ever since the publication of the first reports in 1990 using skeletal muscle as a direct target for expressing foreign transgenes, an avalanche of papers has identified a variety of proteins that can be synthesized and correctly processed by skeletal muscle. The impetus to the development of such applications is not only amelioration of muscle diseases, but also a range of therapeutic applications, from immunization to delivery of therapeutic proteins, such as clotting factors and hormones… CONTINUE READING
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Gene therapy for the treatment of hemophilia B using PINC-formulated plasmid delivered to muscle with electroporation

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