Non-viral gene delivery: from the needle to the nucleus.


Despite nearly two decades of research, the successful application of systemically delivered non-viral gene therapies to treat human disease is still limited by poor transfection efficiency. The major barriers in the circulation and in the cell that limit transfection efficiency have been identified and the field has entered a phase of design and testing of… (More)


Cite this paper

@article{Rettig2007NonviralGD, title={Non-viral gene delivery: from the needle to the nucleus.}, author={Garrett R Rettig and Kevin G. Rice}, journal={Expert opinion on biological therapy}, year={2007}, volume={7 6}, pages={799-808} }